endeneon/VPS45_repo: Multiple genes in a single GWAS risk locus synergistically mediate aberrant synaptic development and function in human neurons

Multiple genes in a single GWAS risk locus synergistically mediate aberrant synaptic development and function in human neurons

Siwei Zhang1,2,‡, Hanwen Zhang1,‡, Marc P. Forrest3,4,‡, Yifan Zhou5, Xiaotong Sun5, Vikram A. Bagchi3,4,6, Alena Kozlova1, Marc Dos Santos3,4, Nicolas H. Piguel3,4, Leonardo E. Dionisio3,4,7, Alan R. Sanders1,2, Zhiping P. Pang8, Xin He5, Peter Penzes3,4,9,10, and Jubao Duan1,2,*

Affiliations

• Center for Psychiatric Genetics, NorthShore University HealthSystem, Evanston, IL 60201, USA
• Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, 60637, USA
• Department of Neuroscience, Northwestern University, Chicago, IL 60611, USA
• Center for Autism and Neurodevelopment, Northwestern University, Chicago, IL 60611, USA
• Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
• Present address: Medical Scientist Training Program, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
• Present address: Neuroscience Interdepartmental Program, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA
• Department of Neuroscience and Cell Biology, Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
• Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
• Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA