CHARACTERISTICS OF THE EMERGENCE OF DRUG RESISTANCE OF THE CAUSATIVE AGENT OF TUBERCULOSIS IN MODERN CONDITIONS

Scientific studies of combinations of M. tuberculosis nucleic acid triplets have revealed that genetic mutations most often affect the locus of the gene responsible for the expression of the KatG enzyme. This also applies to other structural genes, such as inhA, kasA, ahpC, ndh, nat, and mshA [20]. Recent molecular genetic discoveries of tuberculosis infection with MDR have revealed the relationship between antibiotic resistance of mycobacteria and mutations in the KatG genes, as well as inhA, ahpC and rpoB. MDR TB is rightfully considered the most dangerous form of TB, as strains of M. tuberculosis become resistant to the most highly effective anti-TB drugs, rifampicin and isoniazid. The KatG enzyme is responsible for the resistance of pathogenic mycobacteria to the drug isoniazid. Drug-resistant TB complicates the treatment of patients with resistant strains of TB and jeopardizes the global process to achieve the goals of the WHO End TB Strategy. In connection with the above facts, it seems important to study the mutational variability of various strains of mycobacteria in order to create new generation drugs that will be effective in the treatment of tuberculosis infection.