NERVE AGENTS: A BRIEF REVIEW

Nerve agents, are organic chemicals that interrupt the cholinergic transmission to organs by irreversible inhibition of enzyme acetylcholinesterase.⁽¹⁾ This leads to the accumulation of neurotransmitter acetylcholine (ACh), which can ultimately lead to fatality. presently employed antidotal therapy, focused on the reactivation of inhibited AChE, include quaternary pyridinium aldoxime reactivators , is limited to the peripheral circulation because it cannot cross the blood brain barrier (BBB) at therapeutic dose levels due to their positive charge. This review mainly focusesd on the chemistry, and effects of nerve agents and illustrates the description regarding their antidotes.