RESEARCH OF ANTIOXIDANT AND PROOXIDANT PROPERTIES OF GLYCYRRHETIC ACID DERIVATIVES

It was studied the effect of new synthetic derivatives of glycyrrhetic acid (GRA) on the functional mitochondrial parameters, as well as the parameters of the CsA-sensitive pore of mitochondrial membranes in the article. For the first time it was shown that GRA derivatives 2-(N-cytisine)-ethyl-3-0-acetyl-18bH-glycyrrhetate (cytisine-ethyl-HC), 2-(N-cytisine)-isopropyl-3-0-acetyl-18bH-glycyrrhetate (cytisine-isopropyl-HC) and N-(2-pyridyl)-3-0-acetyl-11-ketoolean-12-en-30-amide (2-pyridyl-HC-amide) inhibited the activity of the CsA-sensitive pore and have a protective effect on mitochondrial membranes. At the same time, the damaging effect of Ca²⁺ ions and the LPO process decreases. Other GRA derivatives are N-(4-pyridyl)-3-0-acetyl-11-ketoolean-12-en-30-amide (4-pyridyl-HC-amide) and 2-(N-morpholine)-ethyl-3-0-acetyl-18βH-glycyrrhetate (morpholine-HC) uncouples OXPHOS, enhances the damaging effect of inducers of the CsA-sensitive pore on membranes, increasing their permeability to cations