Published October 7, 2011
| Version v1
Journal article
Open
The acceptance of in silico models for REACH: Requirements, barriers, and perspectives
Creators
- 1. Istituto di Ricerche Farmacologiche “Mario Negri”, Via La Masa 19, 20156 Milano, Italy
- 2. PublicSpace Ltd, Bletherbeck House, Ulverston, LA12 8DB, UK
- 3. Department of Electronics and Information, Politecnico di Milano, Piazza L. da Vinci 32, 20133, Milano, Italy
- 4. Symlog, 262 rue St Jacques, 75005, Paris, France
- 5. CentroReach, Via G. da Procida, 11, 20149, Milano, Italy
- 6. Interdisciplinary Research Unit on Risk Governance and Sustainable Technology Development, University of Stuttgart, Seidenstraße 36, 70174, Stuttgart, Germany
Description
In silico models have prompted considerable interest and debate because of their potential value in predicting the properties of chemical substances for regulatory purposes. The European REACH legislation promotes innovation and encourages the use of alternative methods, but in practice the use of in silico models is still very limited. There are many stakeholders influencing the regulatory trajectory of quantitative structure-activity relationships (QSAR)models, including regulators, industry, model developers and consultants. Here we outline some of the issues and challenges involved in the acceptance of these methods for regulatory purposes.
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