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Published June 20, 2023 | Version 1.0
Preprint Open

Sustainability of FAIR Life Science Resources and Projects: Lessons Learned from EOSC-Life Research Infrastructures

Creators

  • 1. European Research Infrastructure on Highly Pathogenic Agents (ERINHA)
  • 2. University of Dundee
  • 3. European Molecular Biology Laboratory
  • 4. Euro-BioImaging ERIC Bio-Hub, European Molecular Biology Laboratory (EMBL)
  • 5. Instruct-ERIC
  • 6. European Advanced Translational Research Infrastructure (EATRIS)/Lygature
  • 7. VIB Data Core
  • 8. BBMRI-ERIC, Biobanking and BioMolecular Resources Research Infrastructure (BBMRI-ERIC)
  • 9. Flanders Marine Institute
  • 10. IBG-2: Plant Sciences
  • 11. Istituto di Ricerche Farmacologiche Mario Negri IRCCS
  • 12. The University of Manchester
  • 13. INFRAFRONTIER
  • 14. TU Wien, Research Unit Data Science
  • 15. Albert-Ludwigs-Universitat Freiburg
  • 16. European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory
  • 17. University of Ljubljana
  • 18. BBMRI-ERIC Biobanking and BioMolecular Resources Research Infrastructure (BBMRI-ERIC)
  • 19. Dept of Computer Science, The University of Manchester
  • 20. Investigative Science Team, Historic England
  • 21. Universitat Pompeu Fabra, Department of Humanities, CASEs Research Group and ICREA
  • 22. Universite de Montpellier, INRAE, Institut Agro Montpellier
  • 23. Oxford e-Research Centre, Department of Engineering Science, University of Oxford
  • 24. Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche
  • 25. EATRIS ERIC, European Infrastructure for Translational Medicine
  • 26. Escuela Superior de Ingenieros, Universidad de Sevilla/AICIA- Asoc.Invest.Coop.Ind.Andalucia
  • 27. Istituto di Biochimica e Biologia Cellulare, Consiglio Nazionale delle Ricerche (CNR)
  • 28. The Alan Turing Institute, British Library
  • 29. Biobanking and Biomolecular Resources Research Infrastructure (BBMRI-ERIC)
  • 30. European Clinical Research Infrastructure Network (ECRIN)
  • 31. INSERM
  • 32. INFRAFRONTIER GmbH
  • 33. IRCCS Ospedale Policlinico San Martino
  • 34. Department of Chemistry and Magnetic Resonance Center, University of Florence
  • 35. Vall d'Hebron Institut de Recerca, Universitat de Barcelona
  • 36. University of Helsinki
  • 37. Institute for Molecular Medicine Finland, University of Helsinki
  • 38. ELIXIR Hub
  • 39. Group Leader Cloud and HPX, Center for Digital Health, BIH@Charite University Medicine
  • 40. University of Amsterdam, Free University Amsterdam, University of Manchester
  • 41. ITMP Head Discovery Research (ITMP Drug Discovery)

Description

Life Science (LS) communities must increase the sustainability of their data resources, software tools, and workflows, to allow their long-term re-use by the wider scientific community, especially in future applications involving machine-based analyses. Here, we describe key findings regarding sustainable LS resources, based on experiences from the EOSC-Life project. EOSC-Life involves 13 European LS Research Infrastructures. It lays the foundation for an open, digital and collaborative space for biological and medical research. We describe organisational, technical, financial and legal/ethical challenges that represent the main barriers to sustainability in the LS domain. Using lessons from 27 scientific projects selected via open calls, we demonstrate the efficiency of the EOSC-Life support model for sustainable FAIR data management and explore the complex sustainability needs for sensitive- and industry-related data resources. We describe cross-disciplinary sharing of best practices, and how this contributes to the sustainability of knowledge across communities, through building of training resources. We formulate a set of recommendations, focusing on working with experts, and communicating outcomes, to establish strong credibility and recognition of research projects. Furthermore, demonstrating and practising also permit a more sustainable adoption of reproducible research outputs. Recommended measures include sustainable training methodologies, as well as ensuring high quality metadata to drive the sustainable reusability of scientific objects. Responsibilities and roles to ensure sovereignty, sustainable services and tools must also be attributed. Finally, our analysis demonstrates how data harmonisation facilitates interoperability of tools, data, solutions and a better understanding of concepts, functionalities and semantics in the LSs.

Notes

This research is mainly a product of the EOSC-Life European programme funding from the European Union's Horizon Europe research and innovation programme under grant agreement Nº824087. Complementary support was provided through EU funded project AgroServ (grant agreement Nº101058020), EU funded project BY-COVID (grant agreement Nº101046203), EU funded project DANUBIUS-IP (grant agreement Nº101079778), EU funded project EMPHASIS-GO (grant agreement Nº101079772), EU funded project FAIRplus (IMI grant agreement Nº802750), EU funded project FAIRsharing (Wellcome grant agreement Nº212930/Z/18/Z), EU funded project ISIDORe (grant agreement Nº101046133), EU funded project Precision Toxicology (grant agreement Nº965406), UKRI DASH (grant agreement NºMR/V038966/1). Special thanks to T. Biro and her radical collaboration team from Research Data Alliance who gave us great inspiration on how to lead this radical collaboration work.

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PREPRINT_Sustainability of FAIR Life Science Resources_V2_22062023_10_30.pdf

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Additional details

Funding

European Commission
AgroServ - Integrated SERvices supporting a sustainable AGROecological transition 101058020
European Commission
EOSC-Life - Providing an open collaborative space for digital biology in Europe 824087
European Commission
FAIRplus - FAIRplus 802750
European Commission
ISIDORe - Integrated Services for Infectious Disease Outbreak Research 101046133
European Commission
DANUBIUS IP - DANUBIUS Implementation Phase Project - DANUBIUS-IP 101079778
European Commission
PrecisionTox - Toward Precision Toxicology: New Approach Methodologies for Chemical Safety 965406
European Commission
EMPHASIS-GO - Bringing EMPHASIS to operation: European Infrastructure for multi-scale Plant Phenomics and Simulation for food security in a changing climate 101079772
European Commission
BY-COVID - Beyond COVID 101046203