Journal article Open Access
Relevant Physicochemical Descriptors of "Soft Nanomedicines" to Bypass Biological Barriers
Niño-Pariente, Amaya; Nebot, Vicent J.; Vicent, Maria J.
Abstract:
Herein, we present an overview on the current status of the characterization techniques and methodologies used to study the physicochemical descriptors that influence the final clinical performance of a given nanomedicine. The described techniques were selected based on their suitability to operate under relevant “native” conditions that mimic the physiological environment. Special emphasis is placed on those techniques that hold a greater potential to unravel dynamic, structural, and compositional features of soft organic nanomedicines relevant to the ability to bypass biological barriers, and hence allow for the rational design of drug delivery platforms with improved biological output.
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Relevant Physicochemical Descriptors of “Soft Nanomedicines” to Bypass Biological Barriers - Accepted Article - 2015.doc
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| Data volume | 15.4 MB | 15.4 MB |
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- Publication date:
- December 18, 2015
- DOI:
-
- Keyword(s):
- Nanomedicines, Drug Delivery Systems, Biological Barriers, Characterization Techniques, Polymer Therapeutics
- Published in:
- Current Pharmaceutical Design: 22 pp. 1274 - 1291.
- Grants:
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European Commission:
- MyNano - Towards the design of Personalised Polymer-based Combination Nanomedicines for Advanced Stage Breast Cancer Patients (648831)
- Related identifiers:
- New versions:
10.2174/1381612822666151216152143 - License (for files):
- Creative Commons Attribution 4.0 International