PREPARATION AND EVALUATION OF SOLID DISPERTIONS OF EPROSARTAN

In the present study Eprosartan solid dispersions were formulated. The standard curve of Eprosartan was obtained and good correlation was obtained” with R² value 0f 0.999. The medium selected was pH 7.4 phosphate buffer. “Eprosartan was mixed with various proportions of excipients showed no colour change at the end of two months proving no drug excipient interactions” The precompression mix of Eprosartan solid dispersions were characterised with relevance angle of repose, bulk density, broached density, Carr’s index and Hausner’s magnitude relation. The   precompression mix of all the batches indicating sensible to truthful flowability and squeezability. Solid dispersions were ready with varied concentrations of carriers, the ready solid dispersions were compressed into pills by exploitation rotary tablet punching machine, and eight millimeter punch, and with the hardness of 4.5kg /cm2.The developed tablets were evaluated for varied internal control parameters. The tablets were passed all the tests. Among all the formulations F1 formulation containing, Drug and Peg 4000 within the magnitude relation of 1:0.25 showed sensible result that's 94.95 you bored with fifty minutes. Because the concentration of compound will increase the drug unleash was faded. Whereas the formulations containing PEG 6000 showed less unleash. Therefore from the dissolution knowledge it absolutely was evident that F1 formulation is that the higher formulation.

Keywords: Eprosartan, solid dispersions, PEG 4000, PEG 6000.