A REVIEW ON MULTILAYERED TABLET

Bilayer tablets are a new era in the development of successful controlled release models and a variety of products that provide effective drug release. A multilayer tablet has two layers, a slow layer and an immediate release layer. It is based on the development of effective equipment that overcomes the disadvantages of single-layer tablets. Since the API is not compatible with each other, double-layer tablets should be prepared. Therefore, the use of double-layer tablets is very different from the anti-hypertensive drugs, diabetes, anti-inflammatory drugs and analgesic drugs that are often used in combination therapy. Many pharmaceutical companies are currently developing double-layer tablets for various reasons: patent extensions, medical, commercial, etc. The general principles of tablet manufacturing are still the same, but there is a lot to consider because multi-layer tablet manufacturing involves many different materials, accessories, and more designs and competition. This course presents bilayer tablet presses, the challenges in multilayer tablet production, the various tablet presses used, techniques used for bilayer tablet compression, and the latest advances in bilayer technology.

Keywords: Multilayer tablet, Immediate release, Sustained release, Bilayer technology