Lacrimal activity and immunological performance in children with enterovirus uveitis

The control group consisted of 50 healthy people. The study was conducted among 150 children aged from 3 months to 14 years old with uveitis caused by enterovirus uveitis (EVU) in the population of Azerbaijan. They were divided into three groups depending on the etiology of the disease. The first group included 82 children with viral eye diseases; the second group included 42 children with viral-bacterial diseases; the third group included 26 children with viral-allergic eye diseases. One of the factors for the alternative activation of the complement system is considered to be the increase in the level of immunoglobulins of class A that leads to increased vascular permeability and the development of edema, which in turn has chemotoxic and devastating effects. In children with allergic eye changes, the IgE level increases on average by 2.2 times (p<0.05), which indicates an increase in the chemotaxis of eosinophils with eye age. As shown by the survey data, when comparing with healthy children, there is a 3.2-fold increase in the index of intoxication and aggravation of the inflammatory process in 26 sick children (p<0.05), while in 42 children allergy index is on average 2 times higher, increases are observed (p<0.05). At this time, the rise in the leukocyte intoxication index is associated with a decrease in the percentage of nuclear white blood cells and a decrease in the number of lymphocytes. The formation of young and immature forms of neutrophils in the blood of examined children with pronounced eye allergies indicates the strain of compensatory processes providing detoxification. Analysis of the data found that the tear concentration and fibrinogen levels in both groups of patients differed from and between control values indicating an increase in local hemostatic potential. At this time the dynamics of the coagulation activity of lacrimal liquid and the amount of fibrinogen in this pathology indicate the presence of hemocirculatory disorders in the retinal vessels and choroidea, which indicates the importance of the study of hemostasis in inflammatory and allergic processes.