Physicochemical and Biological Characterization of Composites in Hydrogel State made of Collagen, Guar gum and Calcium/Aminoacid based MOFs

Calcium/aminoacids based MOFs (CaHis, CaPhe, and CaTrp) were synthesized by the hydrothermal method. Then, these materials were applied as a filler in the synthesis of composites in hydrogel state based on the biopolymer matrix of collagen-guar gum (CG). The calcium MOFs materials were characterized by ATR-FTIR and XRD, while the morphology, the degradation profile, crosslinking and swelling degree, proliferation and cell viability of porcine dermis fibroblasts were the characteristics analyzed for the composites in hydrogel state. The results indicated that the incorporation of Ca-MOFs into the CG matrix enhances the physicochemical properties of CG, but without affecting their biocompatibility. In this way, the CG-CaTrp demonstrated to be the material with the best physicochemical and biological properties for potential application in tissue engineering of skin.