Probiotics and gut-skin axis - new look on factors affecting skin condition

MAŁOLEPSZA, Aleksandra & DEMBOWSKI, Tomasz. Probiotics and gut-skin axis - new look on factors affecting skin condition. Journal of Education, Health and Sport. 2023;31(1):55-60. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2023.31.01.005

https://apcz.umk.pl/JEHS/article/view/43683

https://zenodo.org/record/7944234

The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343.

Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).

Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.

Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).

© The Authors 2023;

This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland

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The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 24.04.2023. Revised: 10.05.2023. Accepted: 17.05.2023. Published: 17.05.2023.

Probiotics and gut-skin axis - new look on factors affecting skin condition

Aleksandra Małolepsza

Bonifraterskie Centrum Medyczne sp. z o.o Oddział w Krakowie, ul. Trynitarska 11, 31-061 Kraków

ORCID: 0000-0002-0645-7824

ola.malolepsza@onet.pl

Tomasz Dembowski

Bonifraterskie Centrum Medyczne sp. z o.o Oddział w Krakowie, ul. Trynitarska 11, 31-061 Kraków

ORCID: 0000-0002-3323-4036

tomaszdembowski@gmail.com

SUMMARY

Introduction and purpose

The human gut microbiota consists of trillions of microscopic organisms, mostly bacterias. They play a significant role in nutrient metabolism, maintenance of structural integrity of the gut mucosal barrier, immunomodulation and protection against pathogens. Many factors can influence the composition of the intestinal microbiota, for example antibiotics, diet or stress. These factors may lead to dysbiosis which causes activation of neurotransmitters. It can results in the entry of metabolites to the blood stream, systemic immune dysregulation and alteration of skin microbiota. The aim of the study was to review the literature and determine the effects of intestinal microbiota and probiotics in selected skin diseases and what is new - skin aging process.

State of knowledge

We analyzed numerous studies which indicate that disturbed gut microbiota can be related to some chronic diseases, including skin disorders such as atopic dermatitis, acne vulgaris, psoriasis and rosacea. Additionally, it has been proven that bacterial dysbiosis can intensify the skin aging proces. In order to reproduce normal gut microbiota probiotics are used. Despite the fact that there are only a few studies showing the unequivocal effect of probiotics on skin diseases, their results seem to be encouraging.

Conclusions

Proper composition of the intestinal microbiome determines the homeostasis of the human body. Disturbance of the gut microbiome play a significant role not only in development and aggravation of many skin diseases, but also have an impact on the skin aging. Despite quite a lot number of studies assessing the impact of microbiota on certain skin disorders, there is still a need to evaluate impact of probiotics. Researches indicate that they can be used as a helpful therapeutic tool. Taking this into account, it is worth considering it in the treatment process.

Key words: gut microbiota; probiotics; gut-skin axis; skin aging; dermatology