lasseignelab/JLF_Sex_bias_adverse_events: SBAE drug target expression and regulation

Within the scientific literature, it has been identified that women are almost twice as likely to experience undesired drug side effects compared to men, and men are more likely to experience severe drug side effects that result in hospitalization or death. To gain a better understanding about potential genomic causes of these sex-dependent drug responses, we investigated drug side effects that are more likely to be reported by either males or females, known as sex-bias adverse events (SBAEs). In this study, we identified 32 drug metabolism enzymes and 84 drug targets enriched across the known drug targets of the 416 drugs we found associated with SBAEs. Several of these drug metabolism enzymes and drug targets have differences between the sexes in gene expression or gene-regulatory networks representing the relationships between genes and the transcription factors predicted to regulate their expression. Overall, we found an association of sex differences in gene expression and predicted gene-regulatory relationships of drug metabolism enzymes and drug targets that are associated with SBAEs. Additionally, our findings are a resource of SBAE-drug pairs and gene expression profiles for the scientific community.