Published April 30, 2023 | Version v1
Journal article Open

Component composition and antimicrobial activity of subcritical CO2 extract of Ferula asafoetida L., growing in the territory of Kazakhstan

Creators

  • 1. S. D. Asfendiyarov Kazakh National Medical University
  • 2. South Kazakhstan Medical Academy
  • 3. Scientific Center for Anti-Infectious Drugs

Description

Ferula asafoetida L. has been studied for centuries by many scientists as food products and in traditional medicine, which are relevant for Kazakhstan as well. Recent studies have shown that Ferula asafoetida L. has neuroprotective, memory-enhancing, digestive enzymatic, antioxidant, antispasmodic, hypotensive, hepatoprotective, antimicrobial, antitumor, cytotoxic, and anthelmintic effects.

The aim of this study is to determine the component composition by GC-MS method and to study the antimicrobial properties of Ferula asafoetida L. extract obtained by CO2 extraction, which grows in Kazakhstan.

Materials and methods. To determine the possibility of using Ferula asafoetida L., we carried out the component composition of the extract obtained by CO2 extraction in subcritical conditions of the underground part of Ferula asafoetida L. by a certain GC-MS method and also investigated the antimicrobial effect of this extract.

Results. The plant raw materials were collected in accordance with GACP requirements. Conducted subcritical CO2 extraction of plant raw materials showed a 2.5% extraction yield. The study of the component composition by GC-MS revealed 46.3% of sulfate compounds. The determination of antimicrobial activities showed high efficacy against gram-positive (Staphylococcus aureus subsp. Aureus, Bacillus subtilis subsp. Spizizenii), gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae subsp. pneumoniae, Salmonella enterica subsp. enterica) and fungi (Candida albicans, Aspergillus niger).

Conclusions. The possibility of using the obtained CO2 extract of Ferula asafoetida L. in the field of pharmaceutical products as a substance and a drug that has a huge antimicrobial effect

Files

Component composition and antimicrobial activity of subcritical CO2 extract of Ferula asafoetida L., growing in the territory of Kazakhstan.pdf

Files (2.2 MB)

Additional details

References

  • Imanbayeva, A. A., Sarsenbayev, K. N., Sagyndykova, M. S. (2015). Anatomical organization of above- and underground organs of Ferula foetida (Bunge) Regel in Mangistau natural populations. Contemporary Problems of Ecology, 8 (6), 743–753. doi: https://doi.org/10.1134/s1995425515060086
  • Zellagui, A., Gherraf, N., Rhouati, S. (2012). Chemical composition and antibacterial activity of the essential oils of Ferula vesceritensis Coss et Dur. leaves, endemic in Algeria. Organic and Medicinal Chemistry Letters, 2 (1). doi: https://doi.org/10.1186/2191-2858-2-31
  • Tongnuanchan, P., Benjakul, S. (2014). Essential Oils: Extraction, Bioactivities, and Their Uses for Food Preservation. Journal of Food Science, 79 (7), R1231–R1249. doi: https://doi.org/10.1111/1750-3841.12492
  • Iturriaga, L., Olabarrieta, I., de Marañón, I. M. (2012). Antimicrobial assays of natural extracts and their inhibitory effect against Listeria innocua and fish spoilage bacteria, after incorporation into biopolymer edible films. International Journal of Food Microbiology, 158 (1), 58–64. doi: https://doi.org/10.1016/j.ijfoodmicro.2012.07.001
  • Amalraj, A., Gopi, S. (2017). Biological activities and medicinal properties of Asafoetida: A review. Journal of Traditional and Complementary Medicine, 7 (3), 347–359. doi: https://doi.org/10.1016/j.jtcme.2016.11.004
  • Zubaidova, T. M., Dzhamshedov, Dzh. N., Khodzhimatov, M., Nazarov, M. N., Isupov, S. D., Zagrebelnyi, I. A. et al. (2013). Implementation of asafoetida Ferula assafoetida in ancient traditional and modern medicineVestnik Tadzhikskogo natcionalnogo universiteta. Seriia estestvennykh nauk, 1/2 (106), 204–212.
  • Safina, L. K. (2012). Ferula plants of Middle Asia and Kazakhstan. Tr. Inst. Bot. Fitoindukts., 18 (3).
  • Mukhtubaev, S. K. (2010). O sovremennykh tendentciiakh ispolzovaniia feruly voniuchei – (ferula foetida l.) v Iuzhnom Kazakhstane. Vestnik Pavlodarskogo gosudarstvennogo universiteta. Seriia khimiko-biologicheskaia, 1, 87–91. Available at: http://www.elibrary.kz/databases/statia/detail.php?ID=117707
  • Alqasoumi, S., Al-Dosari, M., Al-Howiriny, T., Al-Yahya, M., Al-Mofleh, I., Rafatullah, S. (2011). Gastric antiulcer activity of a pungent spice Ferula assafoetida L. in rats. Farmacia, 59, 750–759. Available at: https://farmaciajournal.com/arhiva/20116/issue62011art03.html
  • Bagheri, S. M., Hedesh, S. T., Mirjalili, A., Dashti-R, M. H. (2016). Evaluation of Anti-inflammatory and Some Possible Mechanisms of Antinociceptive Effect of Ferula assa foetida Oleo Gum Resin. Journal of Evidence-Based Complementary & Alternative Medicine, 21 (4), 271–276. doi: https://doi.org/10.1177/2156587215605903
  • Bagheri, S. M., Dashti-R, M. H., Morshedi, A. (2014). Antinociceptive effect of Ferula assa-foetida oleo-gum-resin in mice. Research in Pharmaceutical Sciences, 9 (3), 207–112.
  • Rezvani, M., Vahidi, A., Esmaili, M., Bagheri, S. (2014). Anticonvulsant effect of ferula assa-foetida oleo gum resin on chemical and amygdala-kindled rats. North American Journal of Medical Sciences, 6 (8), 408–412. doi: https://doi.org/10.4103/1947-2714.139296
  • Nabavi, S. M., Ebrahimzadeh, M. A., Nabavi, S. F., Eslami, B., Dehpour, A A. (2011). Antioxidant and antihaemolytic activities of Ferula foetida regel (Umbelliferae). European Review for Medical and Pharmacological Sciences, 15 (2), 157–164.
  • Prabaharan, C., Thirumavalavan, M., Pachaiappan, R. (2016). Production of antioxidant peptides from Ferula asafoetida root protein. International Journal of Molecular Biology, 1 (1), 19–24. doi: https://doi.org/10.15406/ijmboa.2016.01.00003
  • Seyed Mohammad, N., Dehpour, A. A., Ebrahimzadeh, M. A., Seyed Fazel, N. (2009). Antioxidant activity of the methanol extract of Ferula assafoetidaand its essential oil composition. Grasas y Aceites, 60 (4), 405–412. doi: https://doi.org/10.3989/gya.010109
  • Kavoosi, G., Tafsiry, A., Ebdam, A. A., Rowshan, V. (2013). Evaluation of Antioxidant and Antimicrobial Activities of Essential Oils fromCarum copticumSeed andFerula assafoetidaLatex. Journal of Food Science, 78 (2), T356–T361. doi: https://doi.org/10.1111/1750-3841.12020
  • Ahmadvand, H., Amiri, H., Dehghani Elmi, Z., Bagheri, S. (2014). Chemical Composition and Antioxidant Properties of Ferula-assa-foetida Leaves Essential Oil. Iranian Journal of Pharmacology and Therapeutics, 3 (12 (2)). Available at: http://ijpt.iums.ac.ir/article-1-262-en.html
  • Niazmand, R., Razavizadeh, B. M., Sabbagh, F. (2020). Low-Density Polyethylene Films Carrying ferula asafoetida Extract for Active Food Packaging: Thermal, Mechanical, Optical, Barrier, and Antifungal Properties. Advances in Polymer Technology, 2020, 1–15. doi: https://doi.org/10.1155/2020/4098472
  • Angelini, P., Pagiotti, R., Venanzoni, R., Granetti, B. (2009). Antifungal and allelopathic effects of Asafoetida against Trichoderma harzianum and Pleurotus spp. Allelopathy Journal, 23 (2), 357–368. Available at: https://www.researchgate.net/publication/229832851_Antifungal_and_allelopathic_effects_of_Asafoetida_against_Trichoderma_harzianum_and_Pleurotus_spp
  • Upadhyay, P. K., Singh, S., Agrawal, G., Vishwakarma, V. K. (2017). Pharmacological ac- tivities and therapeutic uses of resins obtained from Ferula asafoetida Linn.: A review. International Journal of Green Pharmacy, 11, S240. doi: https://doi.org/10.22377/ijgp.v11i02.1033
  • Al-Ja'fari, A.-H., Vila, R., Freixa, B., Costa, J., Cañigueral, S. (2012). Antifungal Compounds from the Rhizome and Roots of Ferula hermonis. Phytotherapy Research, 27 (6), 911–915. doi: https://doi.org/10.1002/ptr.4806
  • Lee, C.-L., Chiang, L.-C., Cheng, L.-H., Liaw, C.-C., Abd El-Razek, M. H., Chang, F.-R., Wu, Y.-C. (2009). Influenza A (H1N1) Antiviral and Cytotoxic Agents from Ferula assa-foetida. Journal of Natural Products, 72 (9), 1568–1572. doi: https://doi.org/10.1021/np900158f
  • Bagheri, S., Hejazian, S., Bafghi, A. (2014). Antileishmanial activity of Ferula assa-foetida oleo gum resin against Leishmania major: An in vitro study. Journal of Ayurveda and Integrative Medicine, 5 (4), 223–226. doi: https://doi.org/10.4103/0975-9476.146567
  • Patil, S. D., Shinde, S., Kandpile, P., Jain, A. S. (2015). Evaluation of antimicrobial activity of asafoetida. International journal of pharmaceutical sciences and research, 6 (2), 722–727. doi: https://doi.org/10.13040/ijpsr.0975-8232.6(2).722-27
  • Bagheri, S. M., Abdian-Asl, A., Moghadam, M. T., Yadegari, M., Mirjalili, A., Zare-Mohazabieh, F., Momeni, H. (2017). Antitumor effect of Ferula assa foetida oleo gum resin against breast cancer induced by 4T1 cells in BALB/c mice. Journal of Ayurveda and Integrative Medicine, 8 (3), 152–158. doi: https://doi.org/10.1016/j.jaim.2017.02.013
  • Esmaeili, H., Hafezimoghadam, Z., Esmailidehaj, M., Rezvani, M. E., Hafizibarjin, Z. (2018). The effect of asafoetida essential oil on myocardial ischemic-reperfusion injury in isolated rat hearts. Avicenna Journal of Phytomedicine, 8 (4), 338–349. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204149/
  • Fatehi, M., Farifteh, F., Fatehi-Hassanabad, Z. (2004). Antispasmodic and hypotensive effects of Ferula asafoetida gum extract. Journal of Ethnopharmacology, 91 (2-3), 321–324. doi: https://doi.org/10.1016/j.jep.2004.01.002
  • Rahman, M., Gul, S., Odhano, E. (2008). Antimicrobial Activities of Ferula assafoetida Oil Against Gram Positive and Gram Negative Bacteria. American-Eurasian Journal of Agricultural & Environmental Sciences, 4. Available at: https://www.researchgate.net/publication/242288823
  • Bhatnager, R., Rani, R., Dang, A. S. (2015). Antibacterial activity of Ferula asafoetida: a comparison of red and white type. Journal of Applied Biology & Biotechnology, 3 (2), 18–21. doi: https://doi.org/10.7324/jabb.2015.3204
  • Niazmand, R., Razavizadeh, B. M. (2020). Ferula asafoetida: chemical composition, thermal behavior, antioxidant and antimicrobial activities of leaf and gum hydroalcoholic extracts. Journal of Food Science and Technology, 58 (6), 2148–2159. doi: https://doi.org/10.1007/s13197-020-04724-8
  • Kavoosi, G., Rowshan, V. (2013). Chemical composition, antioxidant and antimicrobial activities of essential oil obtained from Ferula assa-foetida oleo-gum-resin: Effect of collection time. Food Chemistry, 138 (4), 2180–2187. doi: https://doi.org/10.1016/j.foodchem.2012.11.131
  • Samadi, N., Shahani, S., Akbarzadeh, H., Mohammadi-Motamed, S., Safaripour, E., Farjadmand, F. et al. (2016). Essential oil analysis and antibacterial activity of Ferula assa-foetida L. aerial parts from Neishabour mountains. Research Journal of Pharmacognosy, 3 (3), 35–42. Available at: http://www.rjpharmacognosy.ir/article_15635.html
  • Singh, C., Ramendra, P. (2018). Antimicrobial Activity of Resin of Asafoetida (Hing) against Certain Human Pathogenic Bacteria. Advances in Bioresearch, 161–164.
  • Vikas, S., Uma, B., Vijayta, S., Mahajan, N., Vikas, S., Gunjan, S. (2012). Antimicrobial activities of Asafoetida resin extracts (A Potential Indian Spice). Journal of Pharmacy Research, 5, 5022–5024. Available at: https://www.researchgate.net/publication/276271274
  • Divya, K., Ramalakshmi, K., Murthy, P. S., Jagan Mohan Rao, L. (2014). Volatile oils from Ferula asafoetida varieties and their antimicrobial activity. LWT – Food Science and Technology, 59 (2), 774–779. doi: https://doi.org/10.1016/j.lwt.2014.07.013
  • Devanesan, S., Ponmurugan, K., S. AlSalhi, M., Al- Dhabi, N. A. (2020). Cytotoxic and Antimicrobial Efficacy of Silver Nanoparticles Synthesized Using a Traditional Phytoproduct, Asafoetida Gum. International Journal of Nanomedicine, 15, 4351–4362. doi: https://doi.org/10.2147/ijn.s258319
  • Mohan Ch, M., Smitha, P. V. (2011). Phytochemical Composition and Antimicrobial Activity of Three Plant Preparations Used in Folk Medicine and Their Synergistic Properties. Journal of Herbs, Spices & Medicinal Plants, 17 (4), 339–350. doi: https://doi.org/10.1080/10496475.2011.605214
  • Kamble, V. A., Patil, S. D. (2008). Spice-Derived Essential Oils: Effective Antifungal and Possible Therapeutic Agents. Journal of Herbs, Spices & Medicinal Plants, 14 (3–4), 129–143. doi: https://doi.org/10.1080/10496470802598677
  • Fan, X.-D., Hou, Y., Huang, X.-X., Qiu, T.-Q., Jiang, J.-G. (2015). Ultrasound-Enhanced Subcritical CO2 Extraction of Lutein from Chlorella pyrenoidosa. Journal of Agricultural and Food Chemistry, 63 (18), 4597–4605. doi: https://doi.org/10.1021/acs.jafc.5b00461
  • Hawthorne, S. B., Krieger, M. S., Miller, D. J. (1988). Analysis of flavor and fragrance compounds using supercritical fluid extraction coupled with gas chromatography. Analytical Chemistry, 60 (5), 472–477. doi: https://doi.org/10.1021/ac00156a020
  • Bleve, M., Ciurlia, L., Erroi, E., Lionetto, G., Longo, L., Rescio, L. et al. (2008). An innovative method for the purification of anthocyanins from grape skin extracts by using liquid and sub-critical carbon dioxide. Separation and Purification Technology, 64 (2), 192–197. doi: https://doi.org/10.1016/j.seppur.2008.10.012
  • Alimzhanova, M. B., Abilev, M. B., Kuandykova, M. M., Kenessov, B. N., Kamysbayev, D. K. (2012). Rapid Screening Method for the Total Petroleum Hydrocarbons in Water Samples by Solid-Phase Microextraction and GC-MS. Eurasian Chemico-Technological Journal, 14 (2), 177–182. doi: https://doi.org/10.18321/ectj112
  • Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobicall. Approved Standard. CLSI document M07-A10 (2015). Wayne: Clinical and Laboratory Standards Institute. Available at: https://clsi.org/media/1928/m07ed11_sample.pdf
  • Performance Standards for Antimicrobial Susceptibility Testing. CLSI supplement M100 (2018). Wayne: Clinical and Laboratory Standards Institute. Available at: https://clsi.org/media/1930/m100ed28_sample.pdf
  • Farhadi, F., Iranshahi, M., Taghizadeh, S. F., Asili, J. (2020). Volatile sulfur compounds: The possible metabolite pattern to identify the sources and types of asafoetida by headspace GC/MS analysis. Industrial Crops and Products, 155, 112827. doi: https://doi.org/10.1016/j.indcrop.2020.112827
  • Küçük, H. B., Yusufoğlu, A., Mataracı, E., Döşler, S. (2011). Synthesis and Biological Activity of New 1,3-Dioxolanes as Potential Antibacterial and Antifungal Compounds. Molecules, 16 (8), 6806–6815. doi: https://doi.org/10.3390/molecules16086806
  • Ashirov, M. Z., Datkhayev, U. M., Myrzakozha, D. A., Sato, H., Zhakipbekov, K. S., Rakhymbayev, N. A., Sadykov, B. N. (2020). Study of Cold-Pressed Tobacco Seed Oil Properties by Gas Chromatography Method. The Scientific World Journal, 2020, 1–5. doi: https://doi.org/10.1155/2020/8852724
  • Anand Gideon, V. (2015). GC-MS analysis of phytochemical components of Pseudoglochidion anamalayanum Gamble: An endangered medicinal tree. Asian Journal of Plant Science and Research, 5 (12), 36–41. Available at: https://www.imedpub.com/articles/gcms-analysis-of-phytochemical-components-of-pseudoglochidion-anamalayanum-gamble-an-endangered-medicinal-tree.pdf
  • Kozykeyeva, R. A., Datkhayev, U. M., Srivedavyasasri, R., Ajayi, T. O., Patsayev, A. K., Kozykeyeva, R. A., Ross, S. A. (2020). Isolation of Chemical Compounds and Essential Oil from Agrimonia asiatica Juz. and Their Antimicrobial and Antiplasmodial Activities. The Scientific World Journal, 2020, 1–8. doi: https://doi.org/10.1155/2020/7821310
  • Bhatwalkar, S. B., Mondal, R., Krishna, S. B. N., Adam, J. K., Govender, P., Anupam, R. (2021). Antibacterial Properties of Organosulfur Compounds of Garlic (Allium sativum). Frontiers in Microbiology, 12. doi: https://doi.org/10.3389/fmicb.2021.613077