Published March 14, 2023 | Version 01
Journal article Open

On the Modulation of Biocompatibility of Hydrogels with Collagen and Guar Gum by Adding Molybdenum/ aminoacid-based Metal-organic Frameworks

Creators

  • 1. Facultad de Ciencias Químicas, Universidad Autónoma de Coahuila, Ing. J. Cárdenas Valdez S/N, República, 25280 Saltillo, Coahuila, México.
  • 2. Universidad Autónoma de Aguascalientes, Centro de Ciencias Básicas, Av. Universidad #940, C.P. 20131, Aguascalientes, México.

Contributors

Contact person:

  • 1. Facultad de Ciencias Químicas, Universidad Autónoma de Coahuila, Ing. J. Cárdenas Valdez S/N, República, 25280 Saltillo, Coahuila, México.

Description

In this work, we report the synthesis of molybdenum metal-organic frameworks (Mo-MOFs) using 1,3,5-benzenetricarboxylic acid and the amino acids L-phenylalanine, L- tryptophan, and L-histidine as ligands. They were incorporated in hydrogel matrixes comprised of collagen and guar gum to obtain composite hydrogels. The effect of chemical structure of Mo-MOFs on the structure, physicochemical properties and in vitro biocompatibility of hydrogels was studied. These biomaterials showed a super absorbent performance (higher than 2000 ± 169%) and a high degree of reticulation (higher than 75 ± 6%). The microstructure of the composites showed a granular morphology with some porosity. These composites were degraded entirely by hydrolysis at pH 5 and pH 7 at room temperature in time lapses shorter than 15 days. Also, they were biocompatible with porcine dermis fibroblasts not showing cytotoxic effects up to 48 h of incubation allowing its proliferation, and it was observed that the MOF containing L-tryptophan improved notably the biocompatibility of the collagen/guar gum matrix. Finally, the matrixes were tested as vehicles for cell encapsulation and release. The slow-release rates show that fibroblasts tend to remain inside the hydrogel matrixes. Thus, these materials are more suitable for cell scaffolds and tissue engineering applications such as wound healing dressings.

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