Association of Interleukin-8 (Il-8) Level on Benign and Malignant Type of Ovarian Neoplasm

Objective: Ovarian cancer is a global problem and is the eighth most common type of cancer in women. The proinflammatory IL-8 cytokine has been established as an immunoregulatory cytokine. Ovarian cancer cells continuously secrete this cytokine which increases its tumorigenicity

Methods: Observational study with cross-sectional design. The sample of this study were ovarian neoplasm patients who underwent surgery at Dr. Wahidin Sudirohusodo hospital and the networking hospitals. The sampling was done by consecutive random sampling. Measurement of serum IL-8 was conducted using the ELISA method. Data were analyzed by chi-square test.

Result: Serum IL-8 levels were found to be associated with staging and histopathological results in ovarian neoplasms with a significant elevation of IL-8 levels at a mean value of 146.10 pg/mL (p <0.05) in advanced stage ovarian neoplasm and at a mean value of 152.43 pg/mL (p <0.05) in ovarian neoplasm with epithelial histopathology results. Although an increase in serum IL-8 levels was also observed in the ovarian neoplasm group with an abnormal CA-125 result with a mean value of 124.16 pg/mL (p > 0.05), malignant RMI with a mean value of 148.91 pg/mL (p > 0.05), and cytology containing malignant cells with a mean value of 167.68 pg/mL (p > 0.05), these findings were not statistically significant.

Conclusion: In this study, it was concluded that IL-8 levels were significantly increased in ovarian neoplasms with advanced stage and histopathological results of epithelial type.