FORMULATION AND EVALUATION OF ORAL DISINTEGRATING TABLETS OF GRANISETRON

The objective of necessary work to develop Granisetron oral disintegrating tablets using different super disintegrants which would rapidly in oral cavity. Nine batches of Granisetron orally disintegrating tablets were prepared by direct compression method using sodium starch glycolate, crosscarmellose sodium, Crosspovidone as Superdisintegrants in different concentration in order to achieve faster disintegration of tablet. The influence of the Superdisintegrant concentration on the release of Granisetron was studied. The formulation batches were characterized by different physical parameters; physical parameters of all formulated tablets were within acceptable limits. The study reveals that the formulation Sodium starch Glycolate as disintegrant shows faster disintegration compare to others. The F3 formulation was released 96.98% and consider as a optimized.

Key words:  Orally disintegrating tablets, Sodium starch Glycolate, Granisetron, and Direct compression.