FORMULATION AND INVITRO EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF DOMPERIDONE

In the present work, an attempt has been made to develop controlled release tablets of Domperidone by selecting different grade of HPMC like HPMC K4 M, HPMC K15 M and Eudragit S-100 as retarding polymers. All the formulations were prepared by direct compression method. The blend of all the formulations showed god flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Dissolution studies of Domperidone controlled release tablets in media with different dissolution media 0.1N HCl, Phosphate buffer pH (6.8) as per US Pharmacopoeia. The dissolution data revealed that the ratio of polymers is very important to achieve an optimum formulation. The formulation of Domperidone CR tablets shown that formulation F6 with HPMC K4 M (10mg) shown good drug release profile. Among all the formulations F6 formulation showed maximum % drug release i.e., 99.36% in 12 hours  hence it is considered as optimized formulation F6 which contains HPMC K4 M (10mg).

Keywords: Domperidone, HPMC K4 M, HPMC K15 M, Eudragit S-100 and controlled release tablets.