Heamatological Response in Testosterone Propionate Induced Prostatitis Co-Treated with Aqueous Leaf and Seed Extracts of Artocapus Heterophyllus

This study seeks to examine the effects of
aqueous extracts of Artocarpus heterophyllus leaves and
seeds on haematological profile of prostatic male wistar
rats induced using testosterone propionate (TP). One
hundred male wistar rats (100-125g) grouped into 10 of
10 rats each were obtained from the Department of
Pharmacology, University of Port Harcourt Animal
House. The various groups were fed and administered
with various concentrations (100mg/kg, 200mg/kg,
300mg/kg and 200mg/kg combined extract) of the leaves
and seeds extracts of A.heterophyllus. The
haematological profile was done on the male Wistar rats
on day 21, 42 and 63 of the experiment using standard
laboratory methods. Results obtained revealed that the
leaves and seeds extracts were shown to have a
stabilizing and ameliorative effect on the haematological
parameters With PCV (%) range 13.20±0.21 in group 2
at day 42 with maximum values 39.67±0.20 seen in group
5 day 42. HB(g/dl) 5.00±0.15 (group 2 day 63) to
13.23±0.39 (group 5 day 42), RBC(X1012/l) count
1.45±0.14 (group 2 day 42) to 5.93±0.15 (group 5 day
42), WBC (X109/l) 4.07±0.20 (group 5 day 42) to
37.80±0.34 (group 2 day 42), Platelet(X109/l) 201.33±0.09
(group 5 day 42) to 363.00±0.52 (group 2 day 21),
Neutrophils 20.33±0.49 (group 5 day 42) to 49.35±0.34
(group 2 day 42), Lymphocytes 52.30±0.51 (group 5 day
42) to 84.24±0.17 (group 2 day 42), Eosinophils 2.10±0.57
(group 5 day 42) to 9.00±0.53 (group 2 day 42) ,
Monocytes 5.33±0.32 (group 5 day 42) to 12.67±0.53
(group 2 day 42). These values obtained were shown to
be significantly different with the negative control
(induced untreated) group and not significantly different
from the normal and standard drug treated group
revealing high ameliorative potentials especially in
groups 5 (Rats induced with TP 4mg/kg and
administered 200mg/kg of aqueous extract of
Arthocarpus heterophyllus leaves) by day 42.