A RESEARCH STUDY ON EVALUATION OF ANTI- HELMINTHIC ACTIVITY IN METHANOLIC LEAF EXTRACT OF ANANAS COMOSUS - AN INVITRO AND INSILICO APROACH

Helminthic infections are among the most common infection in human affecting large population of the world.As per WHO only few drugs are frequently used in the treatment of these parasite infection.in present study ethanol and methanol extract of ananas comosus leaves were investigated for their antihelminthic  activity against pheretima posthuma. The four concentration ( 10,20,30,50 mg/ml) of each extraxt was studied. These experiment involved in the determination time  of paralysis and time of death of the worms.the gradual increase  in a dose exhibited, a gradual increase in the activity .Methanol extract displayed significant antihelminthic activity at the highest concentration 50mg/ml. Insilico studies have revealed Ltryptophan a natural ligand as the good binding energy score of -97.124 with target protein 1sa0 as compared with that of standard drug albendazole.

Keywords:  Antihelminthic , Ananas comosus, Methanol, pheretima posthuma ,molecular docking , ADMET profile.