The Impact of H63D-Syndrome on Cardiac Function: Evaluating the Risks and Necessity of Regular Heart Monitoring in Affected Individuals

H63D-Syndrome, a genetic disorder resulting from the HFE H63D gene mutation, is associated with increased risks of iron overload and subsequent multi-organ damage. Recent evidence suggests that the heart may be particularly susceptible to damage in patients with H63D-Syndrome due to the affinity of non-transferrin bound iron (NTBI) to sodium, potassium, and calcium channels. This paper aims to review the current understanding of H63D-Syndrome, its effects on cardiac function, and the necessity of regular heart monitoring in individuals diagnosed with this condition.