Canine Intestinal Organoids as a Novel In Vitro Model of Intestinal Drug Permeability: A Proof-of-Concept Study
Creators
- 1. Departments of Veterinary Clinical Sciences, Iowa State University, Ames Iowa, USA
- 2. Office of New Animal Drug Evaluation, Center for Veterinary Medicine, Food and Drug Administration, Rockville, Maryland, MD, USA
- 3. 3D Health Solutions, Iowa State University, Ames, IA, USA
- 4. Department of Biomedical Sciences, SMART Pharmacology, Iowa State University, Ames, IA, USA.
- 5. Department of Veterinary Clinical Sciences, Iowa State University, Ames, IA, United States
- 6. Department of Veterinary Clinical Sciences, Iowa State University, Ames, IA, United States.
- 7. Veterinary Diagnostic Laboratory, Iowa State University, Ames, IA, USA.
- 8. Division of Applied Regulatory Science, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, Food and Drug Administration. Silver Spring, Maryland, MD
Description
Submitted to Cells (MDPI)
Manuscript Title: Canine Intestinal Organoids as a Novel In Vitro Model of Intestinal Drug Permeability: A Proof-of-Concept Study
Dipak K. Sahoo1*, Marilyn N. Martinez2†*, Kimberly Dao3, Vojtech Gabriel4, Christopher Zdyrski3, Albert E. Jergens1, Todd Atherly3, Chelsea Iennarella-Servantez1, Laura E. Burns5, Dwayne Schrunk5, Donna A. Volpe6†, Karin Allenspach1,3 and Jonathan P. Mochel3,4
1Department of Veterinary Clinical Sciences, Iowa State University, Ames, IA, United States.
2Office of New Animal Drug Evaluation, Center for Veterinary Medicine, Food and Drug Administration, Rockville, Maryland, MD, USA.
33D Health Solutions, Iowa State University, Ames, IA, USA.
4Department of Biomedical Sciences, SMART Pharmacology, Iowa State University, Ames, IA, USA.
5Veterinary Diagnostic Laboratory, Iowa State University, Ames, IA, USA.
6Division of Applied Regulatory Science, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, Food and Drug Administration. Silver Spring, Maryland, MD, USA.