HEMATOLOGICAL TOXICITIES ASSOCIATED WITH LONG TERM EXPOSURE TO BENZENE IN SAUDI ARABIA

Background :- the danger of benzene when in contact with the skin or ingestion, but little is known about this substance's danger in the long term by inhalation. This study aims to measure the risk of long-term exposure to benzene among people exposed to it permanently, such as station workers, and to spread sufficient awareness to society in the Kingdom of Saudi Arabia. Materials and Methods:-A 110 Workers size They were divided into four patient groups according to the chronic exposure rate to benzene, one control group, and three other groups of exposures. patient groups 1 (controlled group), patient groups 2 (exposed less than 1y), patient groups 3 (exposed 1-5 y), patient groups 4 (more than 5).  Each group is compared with blood sample parameters (ALT, WBC, MCV, Neutrophils, Eosinophils, Lymphocyte, Monocyte, PLT, Basophils, HB, HEMATOCRIT, MCH, MCHC, AST). Blood samples were drawn from the participants, and statistical tests were performed. Significant change (p≤0.05) was examined compared to the control group. Workers' exposure to benzene led to a significant change in hematological, hormonal, and hepatic factors compared to the control group. Results:- there is a significant correlation between years of exposure and, WBC, MCV, Neutrophils, Eosinophils, Lymphocyte, Monocyte, while there is no significance observed with other values. Conclusion:- We conclude that blood and liver are affected by chronic doses of benzene through inhalation, after our study was on the group most exposed to benzene, which are gas station workers.

Keywords: - Hematological toxicities , benzene, station workers.