Published March 30, 2023
| Version v1
Dataset
Open
Plasticity of neuronal dynamics in the lateral habenula for cue-punishment associative learning.
Creators
- 1. UNIL
- 2. University Tubingen
- 3. Peking University
Description
The brain’s ability to associate threats with external stimuli is vital to execute essential behaviours including avoidance. Disruption of this process contributes instead to the emergence of pathological traits which are common in addiction and depression. However, the mechanisms and neural dynamics at the single-cell resolution underlying the encoding of associative learning remain elusive. Here, employing a Pavlovian discrimination task in mice we investigate how neuronal populations in the lateral habenula (LHb), a subcortical nucleus whose excitation underlies negative affect, encode the association between conditioned stimuli and a punishment (unconditioned stimulus).
Files
7.0-2Photon-analysis -normalization.ipynb
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Additional details
Funding
- Synaptic remodeling for avoidance learning 31003A_175549
- Swiss National Science Foundation