TAU PROTEIN DETECTION BY USING DEVELOPED MICROTUBULE-KINESIN SYSTEM

Lack of intraneuronal transport is a common hallmark of many neurodegenerative diseases including Alzheimer’s disease (AD) [1, 2]. This often involves dysfunction of microtubule associated proteins such as tau, which normally protect microtubule stability and regulate molecular transport along the microtubules. Tauopathies, a large group of age-related neurodegenerative diseases including AD, is characterized by abnormal accumulation of tau protein [3-5]. A reliable and sensitive in vitro assay for rapid analysis of the components and conditions affecting intraneuronal microtubule-based transport would be crucial.