Autophagy in healthy aging and disease
Creators
- 1. Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.
- 2. Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
- 3. Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL, USA.
- 4. Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
- 5. Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, London, UK.
- 6. Department of Physiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
- 7. Department of Molecular Medicine, Institute of Basic Medical Sciences and Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, The University of Oslo, Oslo, Norway.
- 8. Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø-The Arctic University of Norway, Tromsø, Norway
- 9. Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Greece
- 10. Department of Medical Genetics, Cambridge Institute for Medical Research, Cambridge, UK
- 11. Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, London, UK
- 12. Centre de Recherche des Cordeliers, Equipe Labellisée par la Ligue contre le Cancer, Université de Paris, Sorbonne Université, INSERM U1138, Institut Universitaire de France, Paris, France
Description
Autophagy is a fundamental cellular process that eliminates molecules and subcellular elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated degradation to promote homeostasis, differentiation, development and survival. While autophagy is intimately linked to health, the intricate relationship among autophagy, aging and disease remains unclear. This Review examines several emerging features of autophagy and postulates how they may be linked to aging as well as to the development and progression of disease. In addition, we discuss current preclinical evidence arguing for the use of autophagy modulators as suppressors of age-related pathologies such as neurodegenerative diseases. Finally, we highlight key questions and propose novel research avenues that will likely reveal new links between autophagy and the hallmarks of aging. Understanding the precise interplay between autophagy and the risk of age-related pathologies across organisms will eventually facilitate the development of clinical applications that promote long-term health.
Files
s43587-021-00098-4.pdf
Files
(2.2 MB)
| Name | Size | Download all |
|---|---|---|
|
md5:a3fbc9b19d4dcd9a353c63e20df7f44c
|
2.2 MB | Preview Download |