"SYNTHESIS OF VARIOUS ANTHRAQUINONES DERIVATIVES AND ITS BIOLOGICAL EVALUATION AS NEUROPROTECTIVE AGENTS"

Parkinson’s ailment is especially outstanding from other situations based totally on the vital
function of tremors. Oxotremorine-triggered oxidative pressure is a commonplace pathway in
growing Parkinson’s signs like tremors, salivation, and temperature version. Subsequently,
the Oxotremorine-precipitated tremor version changed used to assess Antiparkinsonian
tablets. Distinct Anthraquinones derivatives compound 1 to16 have been formulated using
appropriate schemes 1to 4 to investigate the Antiparkinsonian impact on Oxotremorine-
brought on Parkinson’s symptoms in mice. Procyclidine, an anticholinergic, Antiparkinsonian
drug was administered as a generic drug at a dose of 5 mg/kg p. o., 1hr prior to the
administration of Oxotremorine (0.5 mg/kg) S.C. Numerous synthetic Anthraquinones
compounds administered 200 mg/kg p. o. route of administration to reduce Parkinson’s
symptoms. This look at indicates synthetic Anthraquinones compounds 1, 2, 6, eight, 12, and
14 show marked response to Parkinsonism symptoms compared to Procyclidine. From this
research it is always worthy to synthesize various novel amino Anthraquinones compounds
by considering Carboxamide linkage with various heterocyclic compounds as a
neuroprotective agent helpful in PA.