FORMULATION AND EVALUATION OF SIMVASTATIN MATRIX TABLETS

The Purpose of this Research work was to Formulate and Evaluate Anti-Hyperlipidemic Drug (HMG-coA reductase Inhibitor) in a Controlled discharge dose type of Simvastatin Matrix Tablets.The Tablets were Prepared by utilizing HMPC K15M, HMPC K100M, MicroCrystalline Cellulose , sodium CMC, Magnesium Streate and concentrated with various rate Controlling polymers. The Technique Employed is the Preparation of Matrix Tablet framework by direct Compression Matrix.The Sustainability of the medication is safe,Effective and stable Controlled Release Dosage type of HMPC K100M at centralization of 40mg in blend with Ethyl Cellulose at20mg was seen as acceptable Sustainability and 99% medication discharge in 24 hrs. The enhanced Formulation was assessed with Parameters like Thickness, friability , weight Variation, medicate Content, Invitro Drug discharge and Results were seen as inside the Limits.

Keywords: Matrix tablets, HMPC K15M, HMPC K100M, MicroCrystalline Cellulose, Controlled discharge, Simvastatin