Published April 6, 2021 | Version v1
Journal article Open

REAP: revealing drug tolerant persister cells in cancer using contrast enhanced optical coherence and photoacoustic tomography

Creators

  • 1. Medical University of Vienna
  • 2. AIT Austrian Institute of Technology
  • 3. University of Santiago de Compostela
  • 4. Picophotonics Oy
  • 5. Tampere University
  • 6. Politecnico di Torino
  • 7. InnoLas Laser GmbH
  • 8. LaVision BioTec GmbH, a Miltenyi Biotec Company
  • 9. LioniX International BV

Description

Despite chemotherapy, residual tumors often rely on so-called drug tolerant persister (DTP) cells, which evade treatment to give rise to therapy-resistant relapse and refractory disease. Detection of residual tumor cells proves to be challenging because of the rarity and heterogeneity of DTP cells. In the framework of a H2020 project, REAP will gather researchers and engineers from six countries, who will combine their expertise in biology, chemistry, oncology, material sciences, photonics, and electrical and biomedical engineering in the hope of revealing DTPs in cancer using contrast enhanced multimodal optical imaging. Laser sources for photoacoustic microscopy, photoacoustic tomography, and optical coherence tomography will be developed to enable the design of a two-photon laser scanning optical coherence photoacoustic microscopy system and an optical coherence photoacoustic tomography system. Furthermore, novel photoacoustic detectors using micro-ring resonator will be designed and fabricated, granting improved sensitivity and easier integration of multiple optical imaging modalities into a single system. Innovative algorithms will be developed to reconstruct and analyze the images quickly and automatically. With successful implementation of this four-year project, we can not only gain insight into the mechanisms governing DTPs, but also significantly advance the technology readiness level of contrast agents, lasers, sensors, and image analysis software through joint efforts.

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Liu_2021_J._Phys._Photonics_3_021001.pdf

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Additional details

Related works

Is published in
Journal article: 10.1088/2515-7647/abf02f (DOI)

Funding

European Commission
REAP – Revealing drug tolerant persister cells in cancer using contrast enhanced optical coherence and photoacoustic tomography 101016964
European Commission
SWIMMOT – Switchable magneto-plasmonic contrast agents and molecular imaging technologies 899612
European Commission
SkinOptima – Link Skin Morphology and Vasculature with Diseases using Optical Imaging 894325