Published January 13, 2023 | Version v2
Journal article Open

The Effect of Diabetes and Disease Duration on Disc Degeneration and ‎Subcutaneous Adipose Tissue Thickness

  • 1. Department of Internal Medicine, Adıyaman Training and Research Hospital, Adıyaman, Türkiye.
  • 2. Department of Radiology, Adıyaman University Faculty of Medicine, Adıyaman, Türkiye.
  • 3. Department of Internal Medicine, VM Medical Park Pendik Hospital, Istanbul, Türkiye.
  • 4. Department of Internal Medicine, Adıyaman University Faculty of Medicine, Adıyaman, Türkiye.

Description

Özet

Diyabetes mellitus (DM) varlığı ve hastalık süresinin, intervertebral disk dejenerasyonu, epifizyal plak ‎dejenerasyonu ve cilt altı yağ dokusu kalınlığı değişiklikleri ile ilişkili olup olmadığını belirlemeyi ‎amaçladığımız bu çalışmaya 2020-2022 yılları arasında iç hastalıkları polikliniğine başvuran ve bel ve/veya ‎bacak ağrısı nedeni ile lomber omurga manyetik rezonans görüntülemesi çekilen diyabetik hastalar ve diyabetik ‎olmayan katılımcılar (kontrol grubu) dahil edildi. DM hastaları ve kontrol grubunda disk dejenerasyonu, epifizyal ‎plak dejenerasyonu ve cilt altı yağ dokusu kalınlığı parametreleri retrospektif olarak incelendi ve sonuçlar ‎istatistiksel açıdan değerlendirildi. Hasta grubunda 80 DM hastası vardı, bu hastaların 25’i (%31.3) erkek ve ‎‎55’i (%68.8) kadın idi. Kontrol grubunda ise toplamda 121 katılımcı vardı ve bunların 39’u (%32.2) erkek ve ‎‎82’si (%67.8) kadın idi. Hasta grubun yaş ortalaması 57.85±10.76 iken, kontrol grubunun yaş ortalaması ‎‎54.23±13.09 idi. DM süresi ile disk dejenerasyonu, epifizyal plak dejenerasyonu ve cilt altı yağ dokusu kalınlık ‎değişikliği arasında anlamlı bir fark yoktu. Bununla beraber, kontrol grubu ile DM’li hasta grubu arasında disk ‎dejenerasyonu ve epifizyal plak dejenerasyonu açısından anlamlı derecede farklılık mevcuttu, sırasıyla ‎p=0.003 ve p=0.017. Çalışmamız diyabeti olan hastalarda hastalık süresinden bağımsız olarak disk ‎dejenerasyonu ve epifizyal plak dejenerasyonuna yatkınlığın arttığını göstermiştir. Diyabetik hastalığın ‎kontrolü ve tedavisi sekonder komplikasyonların önlenmesine önemli katkı sunacaktır.

Abstract

In this study, we aimed to determine whether the presence and duration of diabetes mellitus (DM) is ‎associated with changes in intervertebral disc degeneration, epiphyseal plaque degeneration, and ‎subcutaneous fat tissue thickness. Diabetic patients and non-diabetic participants (control group) who applied to the ‎internal medicine outpatient clinic between 2020-2022 and had lumbar spine magnetic resonance imaging ‎due to low back and/or leg pain were included the study. Disc degeneration, epiphyseal plaque ‎degeneration, and subcutaneous fat tissue thickness parameters of DM patients and control group were ‎reviewed retrospectively, and the results were statistically evaluated. There were 80 DM patients in the ‎patient group, 25 (31.3%) of these patients were male and 55 (68.8%) were female. There was a total of ‎‎121 participants in the control group, of which 39 (32.2%) were male and 82 (67.8%) were female. The ‎mean age of the patient group was 57.85±10.76 years, while the mean age of the control group was ‎‎54.23±13.09 years. There was no significant difference between the duration of DM and disc degeneration, ‎epiphyseal plaque degeneration, and subcutaneous adipose tissue thickness. However, there was a ‎significant difference between the control group and the DM patient group in terms of disc degeneration and ‎epiphyseal plaque degeneration (p=0.003 and p=0.017, respectively). This study reveals that patients with ‎diabetes have an increased susceptibility to disc degeneration and epiphyseal plaque degeneration, ‎regardless of disease duration. Control and treatment of diabetic disease will make an important contribution ‎to the prevention of secondary complications‎.

Notes

Diyabet ve Hastalık Süresinin Disk Dejenerasyonu ve Cilt Altı Yağ Dokusu ‎Kalınlığı Üzerine Etkisi

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