Published January 27, 2023 | Version v1
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Phytochemical analysis and Antidiabestic activity of Withania somnifera and Cnidium monnieri using animal models

Creators

  • 1. Food and Biotechnology Research Center, PCSIR Laboratories Complex Ferozpur Road Lahore

Description

Type 2 diabetic is a chronic, non-contagious disease with serious complications. The progression of excess weight leads to the increasing incidence among populations of diabetes mellitus type 2. In form 2 diabetes mellitus instances the median input of obesity is 90%. Moreover, around 174 million individuals worldwide are subject to glucose intolerance, the most prevalent being obesity and metabolic syndrome. There are many therapeutic plants in the medical field and out of these Withania somnifera and Cnidium monnieri are effective against many disorders such as allergy reactions, dermatophytes, many types of bacterial and fungal infections, osteoporotic, weakness, coldness, and skin-related disorders. This study aimed to check out the hypoglycemic, obesity prevention, cytotoxic & hepatoprotective activities of these two plants. The animals were divided into 7 groups, the first group was a normal controlled group and second group was intoxicated. The third group was treated with standard drugs Glucophage and Mevastatin. Rats of fourth, fifth, sixth, and seventh group was treated with extracts of Withania somnifera and Cnidium monnieri in high and low concentrations. As expecting these both gave positive results showing the significant decrease in body weight led to a decrease in insulin level and also had cytotoxic effect that was close to normal value.

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