Portable Optical Fiber based Localized Surface Plasmon Resonance Sensor for in-situ Biosensing
Creators
- 1. School of Physics, Institute for Research in Fundamental Sciences (IPM),
- 2. New York University Abu Dhabi
Description
Abstract
Introduction
Surface plasmon/Localized surface plasmon resonant (SPR/LSPR) nanostructures have exceptional ability to manage and concentrate light at nanoscale level capable of offering multifunctional platforms that are able to perform real-time neuro-interfacing on a wide multi-scale spatial and temporal domains. A portable fiber-optic SPR/LSPR system not only is capable of artifact and labeling free detection of brain activities but also has an inherent advantage of being configured for invasive, non-invasive and multiplex analyses. This study aims to optimize such nanostructures by analyzing their performance through a simulation-based study that will be a platform for the fabrication of a prototype.
Method
FDTD method has been used to analyze a non-periodic 2-D multilayer structure of SiO2, TiO2/ITO with a monolayer of silver gold/silver/Au-Ag alloy nanoparticles nanodomes deposited randomly on it. A fiber-optic refractive index (RI)-based biosensor using LSPR technique is designed for recording brain neural activities. The refractive index (RI) change occurs in the extracellular or intracellular volume, or at the membrane level of a biological sample. A fiber-optic refractive index-based (RI-based)RI based biosensor using SPR/LSPR technique is designed for recording brain neural activities. AThe nanostructure composed of silver nanoparticles to excite localized surface plasmon polaritons (LSPP) has been considered at the fiber end face.
Results and Discussion
The effects of the sublayer ITO or TiO2, nanodome’s shape, and materials on the resonance condition are investigated. The performance of the sensor is optimized based on its sensitivity (shift in the resonant wavelength relative to variations in the refractive index of sensing medium)In realization of the enhancement, we investigate the conditions at which strong localized coupling occurs on the surface of the nanodomes while absorptance of the nanaostructure is maximized. Further, , and its spectral resolution. The geometry structure is optimized to obtain a linear response to change in RI of the sensing medium that varies from 1.3891 332 (representing the cerebrospinal fluid (CSF)) to 1.49 396 (representing plasma vesicles).
Files
Poster_NANOP2019.pdf
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Additional details
References
- Gupta, B, Srivastava, S. K., Verma, R. (2015). Fiber optic sensors based on plasmonics. World scientific.
- Zhang, J., Atay, T., & Nurmikko, A. V. (2009). Optical detection of brain cell activity using plasmonic gold nanoparticles. Nano Letters, 9(2), 519-5242.
- Kim, S.A. Kim, S.J., Moon H. & Jun, S.B. (2012). In vivo optical neural recording using fiber-based surface plasmonresonance. Optics Letters. 37 (4) 614.