Published December 10, 2022 | Version published
Journal article Open

Breaking the resolution limits of 3D bioprinting: future opportunities and present challenges

  • 1. Utrecht University

Description

Bioprinting aims to produce 3D structures from which embedded cells can receive mechanical and chemical stimuli that influence their behavior, direct their organization and migration, and promote differentiation, in a similar way to what happens within the native extracellular matrix. However, limited spatial resolution has been a bottleneck for conventional 3D bioprinting approaches. Reproducing fine features at the cellular scale, while maintaining a reasonable printing volume, is necessary to enable the biofabrication of more complex and functional tissue and organ models. In this opinion article we recount the emergence of, and discuss the most promising, high-definition (HD) bioprinting techniques to achieve this goal, discussing which obstacles remain to be overcome, and which applications are envisioned in the tissue engineering field.

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Funding

VOLUME-BIO – Volumetric light-driven bioprinting capturing complex physiological shape, size and function in artificial tissues and organoids 949806
European Commission
ENLIGHT – ENable LIGHT- and synthetic biology-driven volumetric bioprinting of functional human tissues 964497
European Commission