Antidepressant Activity of Fluoxetine Analogues

Fluoxetine, fluroxamine, sertraline, indalpine, paroxetine, alproclate, femorxetine and choroxamine belong to SSRI group of drugs. Present research work involves synthesis of fluoxetine derivatives by reacting Substituted acetophenone undergoes mannich reaction with substituted secondary amines. In second step mannich bases undergoes reduction with sodium borohydride and in final step etherification was done with the help of p- chlorobenzotrifluride. Structure of final compounds was confirmed by IR, 1 H NMR, and Mass spectral data. Fluoxetine analogues were biologically assessed for antidepressant activity. Since all the five moieties did not show significant decrease in immobility time as compared to the standard drug. This suggests that the fluoxetine and sertraline analogues require further modification to get the desired activity.