Published January 6, 2023
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Integration of proteomic and metabolomic analyses: new insights for mapping informal workers exposed to potentially toxic elements
Creators
- 1. Graduate Program in Translational Medicine, Paulista School of Medicine, Department of Medicine, Federal University of São Paulo, São Paulo, Brazi
- 2. School of Public Health, Department of Environmental Health, University of São Paulo, São Paulo, Brazil
- 3. Department of Chemistry, Institute of Environmental, Chemical, and Pharmaceutical Sciences, Federal University of São Paulo, Diadema, São Paulo, Brazil; Technology School of Teresina, Teresina, Piauí, Brazil.
- 4. Center for Natural and Human Sciences, Federal University of ABC, São Paulo, Brazil.
- 5. Department of Chemistry, Institute of Environmental, Chemical, and Pharmaceutical Sciences, Federal University of São Paulo, Diadema, São Paulo, Brazil.
- 6. Department of Medicine, Imperial College London, Computation and Medicine, London, United Kingdom
- 7. Department of Chemistry, Institute of Environmental, Chemical, and Pharmaceutical Sciences, Federal University of São Paulo, Diadema, São Paulo, Brazil
Description
Occupational exposure to potentially toxic elements (PTEs) is a concerning reality of informal workers engaged in the jewelry production chain that can lead to adverse health effects. In this study, untargeted proteomic and metabolomic analyses were employed to assess the impact of these exposures on informal workeres' exposome. Proteomics analyses were perfomed for saliva samples (n=26), and metabolomic analyses in plasma (n=145) using ultra-high liquid chromatography (UHPLC) coupled with quadrupole-time-of-flight (Q-TOF) mass spectrometry.
Files
Metabolomics_Data.zip
Files
(11.5 GB)
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