Exploring the Impacts of Different Music Genres on Oxidative Stress in Rat Brain and Serum
Creators
- 1. Department of Neurology, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Türkiye.
- 2. Department of Neurology, Erzincan Binali Yıldırım University Faculty of Medicine, Erzincan, Türkiye.
Description
Abstract
Music reduces emotional stress, relieves anxiety, and is utilized while treating various diseases. The present study explored the impacts of various music genres at different decibels on the oxidation state in the brain tissue and serum. We carried out the study on 42 male Wistar Albino rats. The rats were randomized (six rats in each cage) as a control group and groups exposed to noise, rock music, and slow music at different decibels for 21 days and 4 hours a day. At the end of the experiment, we studied oxidant [malondialdehyde (MDA), nitric oxide, protein carbonyl (PC)] and antioxidant [superoxide dismutase (SOD), glutathione peroxidase (GSH-Px)] parameters in the cerebral cortex, cerebellum, and serum. In the cortex, while MDA levels were low in the 100 dB(A) slow music group, the 50 dB(A) noise and rock music groups had elevated SOD, GSH-Px, and MDA levels when compared to the control group and higher MDA and GSH-Px levels when compared to the 50 dB(A) slow music group. In the cerebellum, although SOD levels did not significantly change, we found MDA and GSH-Px to increase in the 50 dB(A) and 100 dB(A) rock music groups and the 50 dB(A) noise group. Finally, we determined MDA and PC levels to be low and SOD levels to be high in the 50 dB(A) slow music group. Overall, that high dB rock music created oxidative stress in cerebellar tissue, that low dB rock music and noise created oxidative stress in the cortex and cerebellum, and that high and low dB slow music may have positive impacts on oxidative stress.
Özet
Müzik, emosyonel stresi azaltır, kaygıyı giderir ve çeşitli hastalıkların tedavisinde kullanılır. Bu çalışmada, farklı desibellerde çeşitli müzik türlerinin, beyin dokusu ve serumdaki oksidatif durum üzerine etkileri araştırıldı. Çalışma 42 adet erkek Wistar Albino cinsi rat üzerinde gerçekleştirildi. Ratlar her kafeste 6 adet olmak üzere 21 gün, günde 4 saat farklı desibel şiddetinde gürültü, rock müzik, slow müzik dinletilen ve kontrol grubu olmak üzere randomize edildi. Deney sonunda serebral korteks, serebellum ve serumdaki oksidan [malondialdehit (MDA), nitrik oksit, protein karbonil (PC)] ve antioksidan [süperoksit dismutaz (SOD), glutatyon peroksidaz (GSH-Px)] parametreler çalışıldı. Kortekste 100 dB (A) slow müzik grubunda MDA düzeyleri düşük iken, 50 dB (A) gürültü ve rock müzik grubunda; kontrolle karşılaştırıldığında SOD, GSH-Px ve MDA düzeyleri, 50 dB (A) slow müzik grubuyla karşılaştırıldığında MDA ve GSH-Px düzeyleri yüksekti. Serebellumda 50 dB (A) ve 100 dB (A) rock müzik ve 50 dB(A) gürültü grubunda SOD düzeyleri değişmemişken, MDA ve GSH-Px düzeyleri artmıştı. Son olarak 50 dB(A) slow müzik grubunda MDA ve PC düzeylerinin düşük, SOD düzeylerinin yüksek olduğunu bulduk. Genel olarak, yüksek dB rock müzik serebellar dokuda ve düşük dB rock müzik ve gürültü korteks ve serebellumda oksidatif stres oluşturdu. Yüksek ve düşük dB slow müziğin ise oksidatif stres üzerine olumlu etkilerinin olabileceği gözlemlendi.
Notes
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