FIXED DRUG ERUPTION DUE TO PARACETAMOL

Fixed drug eruption (FDE) is a form of drug-induced cutaneous adverse event caused by Type IV or delayed cell-mediated hypersensitivity that manifests as a recurrence of a comparable lesion at the same skin or mucosal site after systemic drug exposure. In all age groups of patients, paracetamol is the most usually given analgesic-antipyretic medication. A modest number of pruritic, well-circumscribed, erythematous macules are typical of a fixed drug eruption. These lesions usually reoccur at the same location and go away on their own once the causative substance is stopped. Fixed drug eruption is a well-known but rare side effect of paracetamol, most typically the classic, pigmenting variety encountered in children and teenagers. Paracetamol is a frequently prescribed analgesic and antipyretic with a well-established safety profile. We present a case of a 40-year-old male who had FDE as a result of paracetamol, resulting in generalised necrosis of the skin over his body. Patient presented with burning sensation of eyes along with watering of eyes. He had disturbed sleep secondary to burning sensation. The patient developed erosion in oral cavity since 2 days and also erosion in genitalia along with burning micturition since 1 day. The lesions resolved with a faint lingering hyperpigmentation after 15 days of treatment. Skin biopsy was performed from lesion on right arm. After starting the suggested course of treatment, the symptoms considerably improved.