The Effect of Compounds Belonging Acylhydrazides Schiff Bases of Indol Classes and Sulphones Classes on β-Glucuronidase (In Vitro Research)

12 compounds from acylhydrazides schiff bases of indol classes and 7 compounds from sulphones classes were screened for β-glucuronidase and were determined IC50 (concentration of compound which can inhibit 50 % activity of enzyme). 5 compounds of 12 had not activity, 6 had good activity with compare standard inhibitor (D-saccharic acid 1,4-lacton 48.4± 1.25µl) and 1 has weak activity, while 1 compound is very potent inhibitor from sulphones classes. Comparison between compounds belonging two classes shows if there are halogens in the compounds then this compounds is good inhibitor for β-glucuronidase and level of inhibition increases with this law F→ Cl →Br