Comparative Pharmacological Study Of the Effect Of Collection of "Antidiabet" Galenical Medicines Of Mulberry Leaves and White And Grass Clover Medicinalis on the course of alloxan Modeling Diabetes Mellitus

The main purpose of the study was to evaluate the effect of galenical preparations on the functional and biochemical indices of the disturbance of carbohydrate metabolism using the model of alloxan diabetes. The experiments were performed on adult albino male rats weighing 189-313g. The alloxan diabetes model was created by intraperitoneal injection of 200 mg/kg alloxantrihydrate. The animals were divided into groups of 25 animals each. During 3 weeks mortality, changes of weight, food and water consumption, behavioral activity were observed in the groups. On the 21st day the animals were slain and examined for blood sugar, insulin and C-peptide. The studies revealed that all tested plant preparations contrary to synthetic hypoglycemic agents had a positive influence on the course of the alloxan modeling diabetus mellitus. The number of death cases in the group of animals treated with the studied galenical medicines reduced compared with the control group, but weight of the animals increased. Reversal of diabetic status confirmed decrease in plasma sugar, higher insulin and C-peptide. Our proposed plant collection – phytocomplex "Antidiabet" in all investigated indices exceeds used in medical practice drug "Mirfazin".