Comparative Analysis of Brain Pyruvate Kinase Activity Of White Rats Exposed To Hypoxic Hypoxia During Two Stages Of Prenatal Development

Some relationships between the changes in the dynamics of brain pyruvate kinase (PK) activity and some indices (prenatal period, postnatal period, brain structures, brain subfractions) have been revealed in tissue, cytosol and mitochondrial subfractions of different brain structures of white rats exposed to hypoxic hypoxia in fertilization period, on 14-17 days of prenatal ontogenesis, early ontogenesis (17 - и 30- days) and puberty period (90 days). Comparison of the PK-activity of some brain structures of white rats exposed to hypoxic hypoxia during prenatal ontogenesis revealed tendency towards the restoration of the PK-activity up to control level with increasing postnatal development on 17-, 30- and 90 days. However, the intensity of this process depends on the stage of prenatal ontogenesis subjected to hypoxia.