OVERVIEW; PUBLIC HEALTH APPROACH TOWARD ACUTE LIVER FALIUR AND ITS MANAGEMENT

The purpose of this review was to assess the most recent information about the treatment of acute liver failure (ALF) and to explain the diagnostic strategies that will identify the appropriate treatment for ALF. We evaluate the most recent studies on approaches to acute liver failure, as well as those papers that were published prior to March, 2022. The Midline (PubMed) and Embase databases were searched for papers pertinent to our topic of interest, and then evidence was carefully gathered from each study in order to conduct this review as an up-to-date assessment of all ALF therapy options. Severe liver failure is associated with quickly progressing multiorgan failure and catastrophic complications; nevertheless, emergency liver transplantation has improved patient outcomes. A practice-based evidence base is growing for supportive therapy, and a better knowledge of the pathophysiology of the illness, particularly as it relates to hepatic encephalopathy, will likely lead to additional increases in survival rates in the near future. According to additional research, liver transplantation is the only option with a survival benefit. Liver assist devices and hepatocyte transplantation are still experimental, and additional progress is required. Controlling hepatitis A, B, E, and drug-induced liver injury will reduce the incidence and mortality of ALF.