Study Of Assosation Between Polymorphism Of Interleukin-1 Gene And Perinatal Infections In Newborns

The present research was conducted in order to investigate the existence of association between perinatal infections and polymorphism of interleukin-1 gene in healthy and ill newborns. The study of dependence of in-terleukin-1β (IL-1β) level on etiological factors in newborns (78) showed the highest concentration of this protein during mixed and bacterial infection in comparison with IL-1β cytomegalovirus infection. In order to determine IL-1 gene polymorphism, nucleotide sequences at -889 and +4845; -511, -31 and +3954, +2018 positions of IL-1α, IL-1β və IL-1RA regulator genes were defined, respectively. No statistically significant dependence was observed during research between perinatal infections and polymorphism of other studied positions, except -511 zone of interleukin-1 gene. C allele frequency at -511 position of IL-1β was considerably higher in ill infants than in healthy infants. The obtained results suggest that, existence of polymorphism associated with a single nucleotide substitution at -511 position of IL-1β gene affects the formation and development of perinatal infections as well as increases the risk of infection many times.