Frequency of Occurrence Met235thr Human Angiotensinogene Mutant Variant in Patients with Cardiovascular Diseases

Polymorphism of mutant variant of 235 (C-T) AGT gene was studied by means of complex of modern molecular-genetic methods of diagnosis for the first time in patients with cardio-vascular diseases. The mutation of 235 (C-T) in AGT gene was identified as 37.5% frequency of occurrence. Homozygous mutation type (T/T) was found in patients with severe arterial hypertension, while heterozygous mutation type (T/C) – in patients with severe as well as moderate arterial hypertension. Results of molecular- genetic investigations are of great practical importance. Timely revealing AGT mutation in gene 235 (C-T) will allow doctors to carry out prophylaxis in population with following qualified treatment of arterial hypertension.