The Effect of Statins as Lipid-Lowering Drugs on Lipid Profile Levels in Gallstone Patients

Objectives: This study was designed to determine and compare the effect of statins as lipid-lowering drugs on lipid profile levels (serum total cholesterol TC, triglyceride TG, high-density lipoprotein HDL, low-density lipoprotein LDL, very low-density lipoprotein VLDL) among three groups that including control group (CG), gallstone patients that did not use statin (GSP), and gallstone patients that did use statins (GSPUS). Methods: Blood lipid profiles were determined for the 90 subjects, 30 for CG, 30 for GSP, and 30 for GSPUS using an enzymatic, colorimetric method, by COBAS C system, kits were supplied by Roche /Germany. COBAS C analyzers automatically calculated the concentration of the analyte of each sample. Serum very low-density lipoprotein (VLDL) is calculated through the following equation: VLDL = Triglyceride/5. Results: The levels of biochemical parameters of the lipid profile including serum TC, TG, LDL, and VLDL showed a significant increase in GSP as compared to CG and GSPUS whereas the levels of HDL showed a significant decrease in GSP in comparison to CG and GSPUS (P ≤ 0.05). Conclusions: Statins are effective to reduce TC, TG, LDL, and VLDL levels. So, statins can lower the risk of gallstone disease