Published December 5, 2022 | Version v1
Dataset Open

Single-cell analysis reveals prognostic fibroblast subpopulations linked to molecular and immunological subtypes of lung cancer

Authors/Creators

  • 1. University of Southampton

Description

R Data files associated with datasets generated in our study "Single-cell analysis reveals prognostic fibroblast subpopulations linked to molecular and immunological subtypes of lung cancer". These include a Seurat object holding integrated scRNA-sequencing data for fibroblasts isolated from multiple human lung cancer datasets (IntegratedFibs_Zenodo.Rdata); a dataframe holding histo-cytometry results from multiplexed immunohistochemistry (mxIHC) analysis performed on whole human lung cancer tissue sections; and additional datafiles required to reproduce the paper's figures. Full details and code demonstrating their use in our analysis are provided on Github (https://github.com/cjh-lab/NCOMMS_NSCLC_scFibs).

Notes

This work was supported by Cancer Research UK (CRUK; C11512/A20256), the British Lung Foundation (PPRG17-12) and the Rosetrees Trust (PGS21/10067).

Files

Files (3.1 GB)

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md5:efdeb3975698e9929d92db763c5bf931
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Additional details

Funding

UK Research and Innovation
Characterising cancer-associated fibroblast heterogeneity in lung cancer: relating molecular phenotype to function MR/R001286/1