EVALUATION OF ANTI-HYPERGLYCEMIC EFFECTS OF THE HERB CURCUMA CAESIA ROXB.

The aim of this study is to evaluate anti hyperglycemic potential of Curcuma caesia Roxb. The hydroalcoholic extract from roots of Curcuma caesia was tested Streptozotocin induced diabetes rats. The total phenol & flavonoid content was found to be 6.25± 0.001 µg /ml & 15.63 ± 0.005 µg /ml respectively. Rats were divided into different groups, each group consisting of six animals. Experimental diabetes was induced in group II-VI by intraperitoneal injection of STZ. Glibenclamide (500 mcg/kg) was used as a standard drug. Biochemical parameters like total cholesterol, Triglycerides, HDL & oral glucose were used to assess the antidiabetic activity. Result showed that Hydroalcoholic extract of Curcuma caesia  (HECC) 200 and 400 mg/kg/p.o. was able to decrease body weight (189.00±5.50 and 186.00 ± 9.70)  blood glucose (120.00 ± 5.50 and 116.00 ± 6.00) , cholesterol (139.0 ± 6.00 and 121.0 ± 5.00) & triglycerides (94.00 ± 7.00 and 83.50 ± 5.00) significantly (p<0.05)  at 21st days. The HECC of 200mg/kg & 400mg/kg increased High- density lipoprotein (HDL) (34.00±1.80 and 45.00±1.90) significantly (p < 0.05). It was also noticed that administration of HECC (400 mg/kg b wt.) or Glibenclamide to diabetic rats elicited a significant decrease in blood glucose level at 60 min and beyond. From these finding it can be interpreted that Curcuma caesia Roots possess anti hyperglycemic activity.

Key words: Curcuma caesia, Streptozotocin induced diabetes rats, hydroalcoholic extract