TYPES OF DIABETES MELLITUS INTERLINKED WITH CANCER, OTHER DISEASES, AND COMPLICATIONS WITH OR WITHOUT CANCER

Cancer and type 2 diabetes are both common illnesses around the globe. Diabetes patients clearly have a much higher incidence of cancer. According to epidemiologic research, people with diabetes are much more likely to develop common malignancies such as gastric, pancreatic, urinary tract, breast, liver, colorectal, and female reproductive cancers. Patients with diabetes have a somewhat higher risk of dying from cancer than those without the disease. Though the underlying processes of this putative relationship have not yet been completely explored, there is mounting evidence that some malignancies and diabetes are related. Insulin is a powerful growth agent that stimulates cell division and the development of cancer either directly or indirectly via insulin-like growth factor 1. (IGF1). IGF binding protein-1 is inhibited by hyperinsulinemia, increasing the bioactivity of IGF-1. A more plausible and believable reason for the development of cancer is hyperglycemia. High glucose levels may encourage the development of cancer cells both directly and indirectly. Additionally, persistent inflammation is seen as a characteristic of cancer development. The many medications used to manage diabetes seem to alter the cancer risk. To improve the prognosis of diabetic cancer patients, early cancer detection screenings and proper cancer therapy are crucial. The links between diabetes and common malignancies are outlined in this research along with potential explanations and practical consequences for medical practice.

Keywords: Cancer, Diabetes, Association, Mechanism