Published June 26, 2022 | Version 1.0
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Code for: "Slow TCA flux and ATP production in primary solid tumours but not metastasis"

Creators

  • 1. Department of Chemistry, Princeton University, Princeton, NJ, USA; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA; Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA
  • 2. Department of Chemistry, Princeton University, Princeton, NJ, USA; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA
  • 3. Department of Chemistry, Princeton University, Princeton, NJ, USA; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA;
  • 4. Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA; Department of Molecular Biology, Princeton University, Princeton, NJ, USA.
  • 5. Department of Chemistry, Princeton University, Princeton, NJ, USA; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA; Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA; Current affiliation: Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA, USA.
  • 6. Department of Chemistry, Princeton University, Princeton, NJ, USA; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA; Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA.
  • 7. Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA; Department of Molecular Biology, Princeton University, Princeton, NJ, USA.
  • 8. Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, USA.
  • 9. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Boston, Massachusetts, USA. Department of Biology, Massachusetts Institute of Technology, Boston, Massachusetts, USA
  • 10. Department of Chemistry, Princeton University, Princeton, NJ, USA; Department of Molecular Biology, Princeton University, Princeton, NJ, USA.
  • 11. Department of Chemistry, Princeton University, Princeton, NJ, USA; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA; Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA; Current affiliation: Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
  • 12. Department of Chemistry, Princeton University, Princeton, NJ, USA; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA; Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA; Current affiliation: Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Shanghai, China.
  • 13. Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA.

Description

Tissues derive ATP from two pathways: glycolysis and the tricarboxylic acid (TCA) cycle coupled to the electron transport chain. Most energy production in mammals is via TCA metabolism. We here present the code that enables a model-based calculation of tissue-specific TCA rates from tracer infusion experiments as presented in the paper: “Slow TCA flux and ATP production in primary solid tumours but not metastasis” (reference to be updated upon publication) 

For help and further documentation visit the GitHub page.

 

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