DESIGN AND DEVELOPMENT OF TRIMETAZIDINE HYDROCHLORIDE SUSTAINED RELEASE MICROSPHERES

The meaning of microencapsulation is converting liquids to solids, altering colloidal and surface properties, providing environmental protection and controlling the release characteristics by using the coating materials. Trimetazidine is indicated for the symptomatic treatment of stable angina pectoris in patients inadequately controlled or intolerant to first line therapies. Aim of the study is to formulate Trimetazidine hydrochloride double walled microspheres using different polymers by solvent evaporation method. In the present work, twofold walled microspheres of Trimetazidine hydrochloride utilizing Sodium alginate alongside Carbopol 934 and HPMC K100, Guar gum as copolymers were planned to convey Trimetazidine hydrochloride by means of oral course. Among all plans F7 shows Maximum medication discharge in 12hrs when contrasted and different details. Examination of medication discharge system showed that the medication discharge from the definitions followed the Non fickian dissemination instrument and follows zero request kinectics. In light of the consequences of assessment tests definition coded F7 was closed as best plan.

Key words: Trimetazidine hydrochloride, Sustained release microspheres, Formulation, Evaluation.