Aggregated variant data from whole-genome sequenced tinnitus patients (TIGER)
Authors/Creators
- 1. Otology & Neurotology Group CTS495, Department of Genomic Medicine, GENYO. Centre for Genomics and Oncological Research: Pfizer / University of Granada / Andalusian Regional Government, PTS Granada, Avenida de la Ilustración, 114 - 18016, Granada, Spain.
- 2. Section of Experimental Audiology, Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden.
- 3. Department of Otolaryngology, Instituto de Investigación Biosanitaria, ibs.Granada, Hospital Universitario Virgen de las Nieves, Granada, Spain
- 4. Department of Mathematics, University of Bergen, 5020 Bergen, Norway.
- 5. Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy.
- 6. Section of Experimental Audiology, Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden.et
- 7. Department of Surgery, Division of Otolaryngology, University of Granada, Granada, Spain
Description
Aggregated variant data obtained from tinnitus patients from Sweden.
Uploaded datasets are storage in annotated csv files. Annotation was performed using VEP (v106), including population frequencies for each variant from gnomAD, non-finnish Europeans from gnomAD, and swedish population from SweGen project. Pathogenicity scores from CADD are also annotated for each variant. Variants from genes found to be enriched in a gene burden analysis can be found in this aggregated dataset.
agg.tiger.csv - TIGER cohort is composed by 97 swedish whole-genome sequenced constant tinnitus patients.
agg.jaguar.csv - JAGUAR cohort is composed by 147 swedish whole-exome sequenced tinnitus patients .
agg.sevtin.csv - SEVTIN cohort is a subcohort from TIGER, with 34 WGS patients seggregating severe tinnitus phenotype.
agg.controls.csv - Controls is a swedish population cohort composed by 151 whole-exome sequenced swedish individuals.
Files
Restricted
The record is publicly accessible, but files are restricted to users with access.
Request access
If you would like to request access to these files, please fill out the form below.
You need to satisfy these conditions in order for this request to be accepted:
Aggregated data from this sequencing project is accessible upon request on the platform to the researcher community. Individual data will be made accessible upon request to CR. Cederroth, with qualified investigators whose proposal of data use has been approved for tinnitus research by an independent review committee. A data transfer agreement will have to be established with the Karolinska Institutet.
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